关键词: 儿茶素, 口腔致病菌, 抗菌, 抗炎

Abstract: Catechins are the major active components of tea polyphenols. They exert multiple biological effects including disrupting bacterial membrane structures，inhibiting the expression of virulence factors，scavenging reactive oxygen species and regulating inflammatory pathways，and exhibit potent antibacterial activity against oral pathogens such as Streptococcus mutans and Porphyromonas gingivalis. Catechins have been widely applied in the prevention and treatment of oral diseases，including dental caries，pulp diseases，periapical diseases and periodontal diseases. Nevertheless，catechins are limited by poor stability and low bioavailability. At present，nano-delivery systems or chemical modification strategies can be adopted to improve their properties. This article reviews the research progress regarding the antibacterial mechanisms of catechins against oral pathogens and their clinical applications，aiming to provide new insights for the prevention and treatment of oral diseases.

Key words: catechins, oral pathogenic bacteria, antibacterial, anti-inflammatory