关键词: 牙周炎, 糖尿病, 免疫代谢重编程, 炎症

Abstract: Poor glycemic control leads to immune dysfunction，significantly increasing the risk and severity of periodontitis. As a common oral complication of diabetes，periodontitis not only destroys periodontal supporting tissues and causes tooth loss but may also exacerbate diabetes progression through systemic inflammation，forming a vicious cycle. Recent studies have shown that immunometabolic reprogramming plays a key role in the development of diabetes-related periodontitis -- the hyperglycemic environment induces metabolic pathway remodeling in immune cells，impairing their antimicrobial defense functions and promoting periodontal tissue destruction by modulating the local inflammatory microenvironment. Although some mechanisms have been explored，there remains a lack of systematic understanding of the specific role of immunometabolic reprogramming in diabetes-associated periodontitis and its potential therapeutic targets. This article reviews the research progress of immunometabolic reprogramming in diabetes-related periodontitis and proposes targeted intervention strategies，providing references for clinical treatment.

Key words: periodontitis, diabetes mellitus, immunometabolic reprogramming, inflammation