关键词: 中性粒细胞胞外诱捕网, 牙周炎, 牙髓炎, 根尖周炎, 口腔念珠菌病, 口腔鳞状细胞癌, 口腔-全身疾病轴

Abstract: Neutrophil extracellular traps（NETs）are DNA-protein complexes released by neutrophils，and they play a key role in innate immunity by trapping pathogens. However，their aberrant release can exacerbate inflammation and tissue damage. The dynamic imbalance of NETs serves as a critical driver of disease progression，and targeted degradation or modulation of NETs formation may provide a theoretical foundation for developing novel therapeutic strategies. This paper reviews the research progress in the pathological significance and pathogenic mechanisms of NETs in oral diseases, and proposes that future studies should further elucidate the interactions between NETs and the oral microenvironment，so as to advance clinical translation and promote targeted interventions as well as diagnosis and treatment development of oral diseases.

Key words: neutrophil extracellular traps, periodontitis, pulpitis, apical periodontitis, oral candidiasis, oral squamous cell carcinoma, oral-systemic disease axis