关键词: 炎症性肠病, 牙周病, 微生物, 炎症反应, 信号通路

Abstract: Inflammatory bowel disease and periodontal disease are both chronic inflammatory diseases caused by the interaction between microbial homeostasis imbalance and host immune inflammatory response. The two may interact with each other through direct or indirect mechanisms，thereby promoting the occurrence of another disease or aggravating its original pathological degree. The direct mechanism is the ectopic colonization of oral microbiota in the intestine，which activates the intestinal immune inflammatory response. Indirect mechanisms include systemic immune activation of blood and lymphatic circulation. Due to the similar pathogenic mechanisms between the two，it may be possible to explore prevention and treatment measures for these two diseases by identifying their common targets. Therefore，this article provides a review of the research progress on the correlation between inflammatory bowel disease and periodontal disease as well as the prevention and treatment.

Key words: inflammatory bowel disease, periodontal disease, microbe, inflammatory response, signaling pathway