关键词: Chronic periodontitis is a common oral disease caused by plaque microorganisms, which can lead to destruction of periodontal tissues and even tooth loss, seriously affecting patients' physical and mental health and quality of life. With the development of regenerative medicine, platelet-rich fibrin（PRF）and its derivatives have attracted much attention in clinical periodontal therapy due to their good tissue regeneration induction, ability to accelerate the healing of tissue defects, and bacteriostatic effects. In this paper, we present a review of the research progress in the preparation and biological properties of PRF and its derivatives as well as their application in the treatment of chronic periodontitis, and suggest possible measures for improvement and key points in researches, with an aim to provide clinicians with reference and help them better apply PRF and its derivatives in periodontal therapy to improve the therapeutic effects and quality of life of patients.

Abstract: 慢性牙周炎；富血小板纤维蛋白；联合疗法；牙周治疗

Key words: chronic periodontitis, platelet-rich fibrin, combination therapy, periodontal therapy