Abstract: Ovarian cancer is one of the most lethal gynecological malignancies.Traditional treatment methods include surgery and chemotherapy，but 70% of EOC patients have disease recurrence after initial treatment. In the past two decades，immunotherapy has developed rapidly and has revolutionized the treatment for various types of cancers. Although immunotherapy response rates among ovarian cancer patients remain modest，treatment with immune checkpoint inhibitors，therapeutic tumor vaccines，and adoptive cellular immunotherapy are developing rapidly. At the same time，different combination treatment strategies are also being studied and explored. The challenge remains to be identifying predictive indicators for immunotherapy and determining what treatment combinations are most suitable for this disease. This article reviews the most promising immunotherapies for EOC，hoping to improve the treatment effects on EOC with the continuous development of technology.

Key words: ovarian cancer, immunotherapy, immune checkpoint inhibitors, PD-1/PD-L1, cancer vaccines, adoptive cellular immunotherapy

摘要： 卵巢癌是最致命的妇科恶性肿瘤之一。传统的治疗方法包括手术和化疗，但是，约70%的患者在初始治疗后出现疾病复发。在过去的20年中，免疫疗法迅速发展，并彻底改变了各种癌症的治疗方法。尽管卵巢癌患者对免疫治疗的反应率仍然不高，但免疫检查点抑制剂、治疗性肿瘤疫苗、过继性细胞免疫治疗正在迅速发展。同时不同的联合治疗策略也在研究和探索中。寻找免疫治疗的预测指标、确定哪些治疗组合最适合该类疾病仍然是目前面临的难题。文章回顾了目前针对上皮性卵巢癌（epithelial ovarian cancer ，EOC）最有前途的免疫疗法的研究现状，希望通过技术的不断提高，改善EOC的治疗效果。

关键词: 卵巢癌, 免疫治疗, 免疫检查点抑制剂, PD-1/PD-L1, 肿瘤疫苗, 过继性细胞免疫治疗