Abstract: The women with medical complications such as chronic hypertension，diabetes，systemic lupus erythematosus，antiphospholipid syndrome and chronic kidney disease have a increased risk of preeclampsia and other adverse pregnancy outcomes. Patients with high risk of developing preeclampsia could receive low dose aspirin to prevent preeclampsia. The best pregnancy outcome can be achieved by performing multidisciplinary management and paying attention to the evaluation and treatment of basic diseases.

Key words: preeclampsia, medical complication, prevention, multidisciplinary management

摘要： 合并基础疾病的孕妇，包括慢性高血压、糖尿病、系统性红斑狼疮、抗磷脂综合征、慢性肾病等，其子痫前期和不良妊娠结局的风险明显增高。除了考虑对部分高风险人群采用小剂量阿司匹林进行预防性治疗外，应多学科管理，重视基础疾病的评估和治疗，才能获得最佳的妊娠结局。

关键词: 子痫前期, 内科合并症, 预防, 多学科管理