Preterm prelabor rupture of membranes（PPROM）is one of the obstetrical syndromes that seriously affect maternal and child health.It has a complex etiology with multiple pathways acting synergistically and causally with infection，and its management strategy has been extremely challenging. Management is currently based on the characteristics and prognosis of PPROM at different gestational ages，with emphasis on monitoring for signs of infection，and often requires a trade-off between progression of serious complications and risk of preterm delivery to determine the best time to terminate the pregnancy. However，due to the lack of understanding of the etiology，there is often a lag and passivity in diagnosis and treatment，and a more positive management strategy should focus on low-cost screening and interventions for different etiologies to help advance early prevention，control and refined management of PPROM.