Abstract: Systemic lupus erythematosus （SLE） is an autoimmune connective tissue disease that affects women at child-bearing ages.Adverse pregnancy outcome （APO） occurred in 19.0%-70% of pregnancies with SLE，including recurrent lupus，pregnancy loss，preterm delivery，preeclampsia，fetal growth restriction，neonatal lupus and so on.When the SLE is accompanied specific antibody，such as antiphospholipid antibody，the APO rate increases by 28.4%，and when the SLE is accompanied by anti-Ro /La antibody，the occurrence rate of fetal or neonatal heart block is 1%-2%.Planned pregnancies in stable stage of SLE，close monitoring and individualized multidisciplinary management during pregnancy are keys to improving APO.

Key words: systemic lupus erythematosus, pregnancy, adverse pregnancy outcome

摘要： 系统性红斑狼疮（SLE）是好发于育龄期女性的自身免疫性结缔组织病。系统性红斑狼疮患者发生不良妊娠结局的风险高达19.0%～70%。妊娠合并SLE常见的不良妊娠结局包括狼疮复燃、流产、早产、子痫前期、胎儿生长受限、新生儿狼疮等。当SLE同时伴有特异性抗体如抗磷脂抗体时，不良妊娠结局的发生风险上升28.4%；伴有Ro/La抗体时，胎儿、新生儿先天性心脏传导阻滞发生率为1%～2%。SLE缓解期在医生指导下计划妊娠、孕期严密监测、个体化及多学科管理是改善不良妊娠结局的关键。

关键词: 系统性红斑狼疮, 妊娠, 不良妊娠结局