Abstract:

The physiological and pathological changes of thrombophilia in pregnant women with autoimmune diseases often lead to severe pregnancy complications and adverse pregnancy outcomes.Low molecular weight heparin and aspirin，as the safe pregnancy medication，play an important role in improving the outcomes of these patients.Standardized treatment of anticoagulation helps to improve the maternal and fetal adverse outcomes.

Key words: autoimmune diseases, pregnancy, low molecular weight heparin, aspirin, warfarin

摘要：

妊娠合并自身免疫性疾病患者因病理生理性的血栓形成倾向大大增加，常导致严重的母胎并发症。低分子肝素和阿司匹林等抗凝药物作为妊娠期安全用药，在改善此类患者的母胎结局中发挥着重要作用。因此，规范抗凝治疗有助于改善母胎不良结局。

关键词: 自身免疫性疾病, 妊娠, 低分子肝素, 阿司匹林, 华法林