中国实用儿科杂志

中国实用儿科杂志 ›› 2023, Vol. 38 ›› Issue (11): 842-845.DOI: 10.19538/j.ek2023110608

• 专题笔谈 • 上一篇    下一篇

胰岛素样生长因子在儿童矮身材中的诊断价值

  

  1. 浙江大学医学院附属儿童医院内分泌科，浙江  杭州  310052  
  • 出版日期:2023-11-06 发布日期:2023-11-02
  • 通讯作者: 董关萍，电子信箱：dgpxlx@163.com

Diagnostic value of IGF-1 in children with short stature

  1. Department of Endocri-nology，Children's Hospital，Zhejiang University School of Medicine，Hangzhou  310052，China
  • Online:2023-11-06 Published:2023-11-02

摘要： 儿童矮身材是儿童生理及心理问题的危险因素之一，需早诊断、早治疗，但儿童矮身材病因复杂，明确病因需进行综合评估。胰岛素样生长因子-1是儿童矮身材的病因检查评估的一个重要指标，尤其对生长激素缺乏症和生长激素抵抗。胰岛素样生长因子-1主要受生长激素调控，但其他影响因素较多，且目前各实验室检测结果差异性较大，使胰岛素样生长因子-1的应用受到局限。

关键词: 儿童, 矮身材, 胰岛素样生长因-1, 诊断

Abstract: Short stature in children is one of the risk factors for physical and psychological problems，and early diagnosis and treatment are required. However，the etiology of children's short stature is complex，so a comprehensive evaluation is required to determine the cause. Insulin-like growth factor-1 is an important index in the evaluation of the etiology of short stature in children，especially for growth hormone deficiency and growth hormone resistance. Insulin-like growth factor-1 level is not only influenced by GH，but also by other factors，and immunoassays for IGF-1 suffer from poor concordance among platforms，which limits the broad application of insulin-like growth factor-1.

Key words: child, short stature, insulin-like growth factor-Ⅰ, diagnosis