中国实用儿科杂志

中国实用儿科杂志 ›› 2023, Vol. 38 ›› Issue (8): 580-584.DOI: 10.19538/j.ek2023080605

• 专题笔谈 • 上一篇    下一篇

儿童注意缺陷多动障碍遗传学研究进展

  

  1. 1.安徽医科大学附属巢湖医院精神科，安徽合肥 238000；2.安徽省精神医学中心，安徽合肥 238000；3.安徽医科大学精神卫生与心理科学学院，安徽合肥 230032
  • 出版日期:2023-08-06 发布日期:2023-08-29
  • 通讯作者: 刘寰忠，电子信箱：huanzhongliu@ahmu.edu.cn

Research progress in genetics of attention deficit hyperactivity disorder in children

  1. *Department of Psychiatry，Chaohu Hospital of Anhui Medical University，Hefei 238000，China
  • Online:2023-08-06 Published:2023-08-29

摘要： 注意缺陷多动障碍（attention deficit hyperactivity disorder，ADHD）是儿童最常见的神经发育障碍之一，病因复杂，遗传因素在儿童ADHD的发生和发展过程中起到了关键的作用，遗传率高达75%。该文就儿童ADHD遗传学研究进展进行总结，主要从候选基因，全基因组关联研究（GWAS），表观遗传学，基因拷贝数变异（CNVs）等方面展开讨论，以了解儿童ADHD的遗传学研究进展，进一步帮助医务工作者从遗传学方面增加对该病的认识。

关键词: 注意缺陷多动障碍, 基因遗传学, 儿童

Abstract: Attention deficit hyperactivity disorder （ADHD） is one of the most common neurodevelopmental disorders in children with a complex etiology，and genetic factors play a pivotal role in the development of ADHD in children，with a heritability rate as high as 75%. This paper now summarizes the progress of genetic research on childhood ADHD，starting from candidate genes，genome-wide association studies （GWAS），epigenetics，and gene copy number variants （CNVs），in order to understand the progress of genetic research on childhood ADHD and further help medical practitioners to increase their understanding of the disease from genetic aspects.

Key words: attention deficit hyperactivity disorder, genetics, child