Abstract:

Chronic kidney disease（CKD），defined as kidney damage for three or more months associated with structural or functional abnormalities of the kidney，with or without decreased glomerular filtration rate （GFR），is associated with periodontal disease，an infectious oral disease leading to tooth loss. Many epidemiological evidences have recently suggested that CKD is highly prevalent among patients with periodontal disease. Moreover，periodontal disease may also increase the morbidity and severity of CKD and is associated closely with poor prognosis，according to some researches in recent years. However，the detailed mechanism on how periodontal disease debilitate and worsen CKD is yet not clear. Some researchers hypothesize that periodontal disease could exert an influence on CKD via periodontal pathogens，inflammatory mediator and oxidative stress. This review presents certain aspects of possible link between periodontal disease and CKD and provides references for combined clinical treatment.

Key words: periodontal disease, chronic kidney disease, correlation, oxidative stress, inflammatory mediator

摘要：

慢性肾病是各种原因引起的肾脏结构或功能异常 ≥ 3个月，伴或不伴有肾小球滤过率下降，或不明原因的肾小球滤过率下降（< 60 mL/min/1.73 m2）超过3个月。牙周病是发生在牙齿支持组织的慢性炎症性疾病。许多研究发现，慢性肾病患者牙周病的发病率显著高于普通人群，牙周病亦可增加慢性肾病的发病率与严重程度，且与后者的不良预后密切相关。但目前关于牙周病诱发或加重慢性肾病的机制尚不明确，可能与牙周致病菌、炎症因子及氧化应激等途径有关。文章就近年关于牙周病与慢性肾脏病的关系、可能的关联机制以及牙周治疗对慢性肾病预后影响等方面的研究文献进行综述，以期为临床开展二者的联合防治提供借鉴。

关键词: 牙周病, 慢性肾脏病, 关联性, 氧化应激, 炎症因子