Abstract:

Oral implant technology can effectively repair dentition defects and loss. Compared with the traditional repair method，the implant is more beautiful，has strong retention，high chewing efficiency and little foreign body sensation，and can delay the absorption of alveolar bone. The oral specific stem cells involved in the oral implant repair process have the ability of rapid proliferation，migration，osteogenic differentiation and mineralization. The osteogenic differentiation ability is a key factor affecting the stability of implant osseointegration，which directly affects the oral repair process. Non-coding RNA （ncRNA） is a type of RNA that does not have coding function，which can regulate the osteogenic differentiation of various cells at the transcriptional and post-transcriptional levels. At present，most reported ncRNAs are microRNAs（miRNAs），long non-coding RNAs（lncRNAs）and circular RNAs（circRNAs）. This review summarizes the research progress in the role of ncRNA during osteogenic differentiation.

Key words: oral stem cells；microRNA, miRNA；long non-coding RNA, lncRNA；circular RNA, circRNA； osteogenic differentiation

摘要：

应用口腔种植技术能够有效修复牙列缺损和牙列缺失。与传统修复方法相比，种植体更加美观、固位力强、咀嚼效率高、异物感小，并且可延缓牙槽骨的吸收。参与种植修复过程的口腔特有的干细胞具有快速增殖、迁移、成骨分化及矿化能力，其中成骨分化能力是影响种植体骨结合稳定程度的一个关键因素，直接影响口腔修复进程。非编码RNA（non-coding RNA，ncRNA）是一类不具备编码功能的RNA，其可在转录及转录后水平调控多种细胞的成骨分化。目前报道较多的ncRNA主要有微小RNA（microRNA，miRNA）、长链非编码RNA（long non-coding RNA，lncRNA）和环状RNA（circular RNA，circRNA）。文章对成骨分化过程中ncRNA作用的研究进展进行综述。

关键词: 口腔干细胞, 微小RNA, 长链非编码RNA, 环状RNA, 成骨分化