Abstract:

Oral lichen planus （OLP） is a common oral mucosal chronic disease，the prevalence rate is 0.1% to 4.0% of the general population，and it occurs mostly in women aged 30 to 60. OLP pathogenesis has not yet been clear；currently it is considered as a class of T cell-mediated autoimmune diseases. It is related to genetics，drug，infection，oral irritation and mental factors. The clinical manifestations are white or gray textures，pimples，plaques，etc.，which may be accompanied by congestion，erosion，blisters and other lesions. Because 1.1% of OLP will develop into oral squamous cell carcinoma，World Health Organization lists it as a potentially malignant disease，and clinicians should pay attention accordingly. Here we summarize the pathogenesis，diagnosis and treatment of OLP.

Key words: oral lichen planus, pathogenesis, diagnosis, treatment

摘要：

口腔扁平苔藓（oral lichen planus，OLP）是一种常见的口腔黏膜慢性炎性疾病，患病率为0.1%～4.0%，好发于30～60岁女性。OLP发病机制尚未明确，目前认为是一种由T细胞介导的自身免疫疾病，与遗传、药物、感染、口腔局部刺激、精神因素等相关。OLP临床表现为白色或灰白色的网纹、丘疹、斑块等，其间可伴充血、糜烂、水疱等病损。有1.1%的OLP会发展为口腔鳞状细胞癌，WHO将其列为潜在恶性病变，临床医生应予以相应的重视。文章针对OLP的发病机制、诊断与治疗进行总结。

关键词: 口腔扁平苔藓, 发病机制, 诊断, 治疗