Abstract: Objective　The aim of this study is to explore the correlation between serum vitamin A，D and E levels and children's picky eating problem. Methods　We collected clinical data of children over 2 years old who were hospitalized in the health care clinic of Capital Institute of including height，weight and other physical measurements. Their serum vitamin A and vitamin E levels were measured by high performance liquid chromatography（HPLC）and serum 25-（OH）D levels were measured by high performance liquid chromatography tandem mass spectrometry（HPLC-MS/MS）. The children were divided into healthy group and picky eating group.In data analysis，SPSS 21 software was employed to perform test of normality，chi-square test and logistic regression analysis，et al. Results　A total of 109 children were included including 71 children in the healthy control group and 38 children in the picky eating group. The vitamin E level of the control group was（8.51±2.29）mg/L，and that of the picky eating group was（7.55±1.62）mg/L，the difference was statistically significant（P＜0.05）. The weight-for-age Z-scores（WAZ），height-for-age Z-scores（HAZ）， BMI-for-age Z-scores（BAZ）were -（0.04±1.17），（0.18±1.05），-（0.25±1.24）respectively，while those of the picky eating group were -（0.95±0.99），-（0.35±0.92），-（1.14±1.43），respectively，with statistical significance（P＜0.05）. The deficient and insufficient constituent ratio of serum vitamin E in picky eating group was 50.0%，which was much higher than that of control group（23.9%），the difference was statistically significant （P＜0.05）. The proportions of serum vitamin A below normal level in the two groups were 31.0% and 28.9% and the proportions of serum 25-（OH）D below normal level were 68.0% and 58.8%，respectively. There were no significant differences between the two groups. Binary logistic regression analysis showed that picky eating had a significant impact on Vitamin E level（OR=0.773，95% CI：0.606-0.985），there was no significant effect on the level of vitamin A and 25-（OH）D（P＞0.05）. Conclusion　The vitamin E level of picky eating children was lower than that of healthy control group,and the deficient and insufficient ratio were high. Attention should be paid to the serum vitamin E level of children with picky eating behavior and dietary guidance.

Key words: child, picky eating, vitamin E 

摘要： 目的　探讨血清维生素A、D、E水平与儿童挑食问题的相关性。方法　收集首都儿科研究所附属儿童医院儿童保健门诊2018年12月至2019年11月就诊的2岁以上普食儿童临床资料，包括身高、体重等体格测量数据，采用高效液相色谱法测定儿童血清维生素A、E水平，液相串联质谱法测定血清25-（OH）D水平。入组儿童分为健康对照组和挑食组，所有数据应用SPSS 21软件进行正态性检验、卡方检验和回归分析等处理。结果　共纳入儿童109名，其中健康对照组71名，挑食组38例。对照组维生素E水平为（8.51±2.29）mg/L，挑食组儿童维生素E 水平为（7.55±1.62）mg/L，差异有统计学意义（P＜0.05）。对照组儿童年龄别体重Z评分（WAZ）、年龄别身高Z评分（HAZ）、年龄别体重指数（BMI）Z评分（BAZ）分别为-（0.04±1.17）、（0.18±1.05）、-（0.25±1.24），挑食组儿童的分别为-（0.95±0.99）、-（0.35±0.92）、-（1.14±1.43），差异均有统计学意义（P＜0.05）。挑食组儿童血清维生素E水平缺乏和不足的比例高达50.0%，远高于对照组儿童23.9%，差异有统计学意义（P＜0.05）。健康组儿童和挑食组儿童血清维生素A低于正常水平比例分别为31.0%、28.9%，血清25-（OH）D低于正常水平的比例分别为68.0%、 58.8%，差异均无统计学意义。Logistic回归分析显示，挑食行为对维生素E水平有显著影响（OR =0.773，95%  CI：0.606～0.985），对维生素A、25-（OH）D水平没有显著影响（P＞0.05）。结论　挑食儿童维生素E水平低于健康对照组，缺乏及不足比例高，应关注挑食行为儿童血清维生素E水平及膳食指导。

关键词: 儿童, 挑食, 维生素E