Abstract: Atopic dermatitis (AD) is a chronic, inflammatory skin disease in children, with a high incidence and characterized with recurrent attacks. Due to limitations of drug selection in infants and children, topical drugs are the mainstay of treatment for pediatric AD. with the deepening research in its pathogenesis, small-molecule inhibitors targeting specific inflammatory pathway in the pathogenesis of AD have been gradually in clinical use, to significantly improve symptoms and reduce recurrences, improve the quality of life of AD children and their families.

Key words: child, atopic dermatitis, treatment, PDE-4 inhibitors, JAK-STAT inhibitors

摘要： 特应性皮炎（atopic dermatitis，AD）是儿童最常见皮肤疾病，发病率高且呈慢性病程，可反复发作。由于对儿童AD的系统治疗存在局限性，故外用药物是其主要手段。近年来，随着对发病机制研究的逐步深入，针对AD发病过程中关键炎症因子的靶向抑制剂也逐渐应用于AD的临床治疗，以期在显著改善症状的同时能够减少复发，提高患儿及其家长的生活质量。

关键词: 儿童, 特应性皮炎, 治疗, 磷酸二酯酶Ⅳ抑制剂, JAK-STAT抑制剂