Abstract: Eosinophilic gastroenteritis（EGE） is a rare chronic digestive system disease in children，characterized by eosinophilic infiltration in the gastrointestinal tract. According to the location of eosinophil infiltration，it can be divided into mucosal type，muscular type，serosal type and mixed type. The clinical manifestations of the disease are various，often with occult onset and repeated attacks. Histopathological examination is the basis of diagnosis. Some children have a history of food allergy. Dietary therapy and hormone therapy are the main treatment methods. Biological agents treatments based on immune inflammatory targets are one of the research hotspots. It is difficult to be diagnosed and easy to relapse，so standard treatment and follow-up are needed.

Key words: child, eosinophilic gastroenteritis, pathogenesis, diagnosis, treatment

摘要： 嗜酸性粒细胞性胃肠炎（EGE）是一种儿童少见的慢性消化系统疾病，以胃肠道嗜酸性粒细胞浸润为特征。根据嗜酸性粒细胞浸润的部位分为黏膜型、肌型、浆膜型及混合型。该病临床表现多种多样，常隐匿起病，反复发作。组织病理学检查是确诊的依据。部分患儿有食物过敏病史。治疗以膳食疗法、激素治疗为主，基于免疫炎症靶点的生物制剂治疗是研究的热点之一。该病诊断较困难，容易复发，需进行规范治疗及随访。

关键词: 儿童, 嗜酸性粒细胞性胃肠炎, 发病机制, 诊断, 治疗