Objective:To evaluate the clinical effect of intraoperative cholangiography (IOC) combined with laparoscopic ultrasonography (LUS) for detection of occult common bile duct stones (CBDS) at laparoscopic cholecystectomy. Methods:From December 2002 to August 2005,103 patients with intermediate and moderate levels of suspicion of CBDS underwent IOC and LUS simultaneously during LC were analyzed prospectively. Results:The successful rate of IOC and LUS were 91.3% and 100% respectively.The time required for LUS (8.5±1.9)min was significantly shorter than for IOC (13.8±3.7)min (P<0.01).The sensitivities,specificities,accuracies,positive and negative predictive values,positive and negative likelihood ratios identifying occult CBDS were 75.0%,98.7%,92.2%,95.5%,91.4%,57.7 and 0.253 by IOC,and 82.1%,98.7%,94.2%,95.8%,93.7%,63.2 and 0.181 by IUS respectively.The McNemar test showed no significant difference between two methods (P=0.754) with a higher diagnosis concordance (KAPPA coefficient=0720).The sensitivity of IOC combined with LUS was 92.9%,which was clearly superior to that of IOC and LUS taken separately. Conclusion:LUS can be performed in case IOC has failed or is contraindicated.The combination of both methods maximizes intraoperative detection of CBDS and should be recommended.