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    08 October 2007, Volume 27 Issue 10 Previous Issue    Next Issue

    论著
    临床研究生园地
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    论著
    Hepatic segmentectomy by regional vascular occlusion at hepatic hilum:a report of 335 cases
    ZHENG Guang-qi
    2007, 27(10): 1-823. 
    Abstract ( )   PDF (390KB) ( )  

    Objective:Present the experience on a variety of hepatectomy by occluding the branches of hepatic artery(HA) and portal vein(PV) to the liver lobe,segment or subsegments in hilar H fissure for 335 patients from 1978 to 2006. Methods:According to the size and location of liver tumor,major hepatectomy (65 cases),resection of separated hepatic subsegments (15cases,HS),resection of adjacent HS (209 cases),and resection of single HS(46 cases) were used to treat these patients. Results:(1)Operative mortality rate was 3.0%(10/335,8 for liver failure and 2 for bleeding)(2)Longterm survival:8 HCC patients survived for 10-19 years.11,5,4 years survival for 1 patient respectively in hilar cholangiocarcinoma.1/2-3years survival for intrahepatic cholangiocarcinoma.1/2-1 year survival for carcinoma of gallbladder.All patients of benign liver diseases were cured. Conclusion:(1)Separated multiple hepatic subsegmentectomy is an effective procedure in one operation to cure the compacted stones in 2-6 subsegmental hepatic ducts both in right and left lobes.(2)This procedure is reasonable,effective and low cost for hepatectomy.(3)Current treatment of B hepatitis is essential for preventing metastasis or recurrence after resection of HCC associated with B hepatitis based on the experience of longterm survivals.

    Effect of preoperative biliary drainage on hilar cholangiocarcinoma in patients underwent resection operation
    CHEN Dong,PENG Bao-gang,LI Shao-qiang,et al.
    2007, 27(10): 1-828. 
    Abstract ( )   PDF (551KB) ( )  

    Objective:To investigate the effect of preoperative biliary drainage (PTBD) on hilar cholangiocarcinoma in patients underwent resection operation. Methods:Data of 58 cases of patients with hilar cholangiocarcinoma underwent resection operation whose total bilirubin (TB) over 85μmol/L was collected from Jan,1999 to Dec,2005,the postoperative morbidity and the potential effect of PTBD on morbidity were analyzed. Results:Thirtyone(53.4%,31/58) cases received PTBD procedure and the mean drainage duration was 9 days.The total bilirubin was significantly reduced from (292±103)μmol/L to(214±125)μmol/L and was significantly lower than 382±174μmol/L of nonPTBD group,the PTBD procedure can reduce the level of AST,GGT,ALP,DB.The overall postoperative morbidity was 55.2%(32/58).The morbidity in PTBD group was 58% (18/31) and 52%(14/27)in nonPTBD group and there was no significance between the two groups,and so did in the single complication.The hospital stay duration was significantly longer in the PTBD group than in the nonPTBD group.whether hepatectomy or not was important risk factor for postoperative death and TB over 340μmol/L was important risk factor for postoperative renal dysfuntioin. Conclusion:PTBD procedure can reduce the total bilirubin level and improve the hepatic function of the patients.The resection operation of hilar cholangiocarcinoma was still a procedure with high risk.The high TB level can increase the possibility of postoperative renal dysfunction.However,there was no relationship between PTBD procedure and postoperative complication and death.

    Effects of preoperative biliary drainage in the patients with malignant obstructive jaundice
    SHI Li,TIAN Fu-zhou,CAI Zhong-hong,et al.
    2007, 27(10): 1-815. 
    Abstract ( )   PDF (285KB) ( )  

    Objective:To investigate the technique of ultrasound guided percutaneous transhepatic biliary drainage (UPTBD) on patients with malignant obstructive jaundice. Methods:Analysis on the clinical data of 516 patients with UPTBD using the general probe. Results:Success rate of catheterization:97.1%,success rate of the first puncture:72.3%,average time with catheter in place:18.4 days,average volume of bile drainage:420 ml/day,complication rate 0.58%. Conclusion:Bile duct to be punctured should be the second or smaller branches.Diameter of the bile duct to be punctured should be greater than 0.4 cm.16-18G needles are applicable to the 0.4-0.5cm bile duct,6F needle is applicable to 0.5-0.6cm bile duct,7F needle can be selected for bile duct greater than 06cm.Catheter inserting depth greater than 5 cm,with appropriate movement restriction can prevent drainage tube from falling off.General probe guidance is more conducive to the operation.

    Proper timing of definitive surgery in malignant obstructive jaundice after biliary decompression
    TIAN Fu-zhou,SHI Li,TANG Li-jun,et al.
    2007, 27(10): 1-823. 
    Abstract ( )   PDF (420KB) ( )  

    Objective:To investigate the best operation opportunity of the malignant obstructive jaundice patients accepted the treatment of decrease their jaundice index before surgery. Methods:One hundred and sixtyseven cases of malignant obstructive jaundice patients were accepted percutaneous transhepatic biliary drainage by ultrasonic guidance, analysis their jaundice index descending rate ,tumor resection rate, incidence of complication. Results:One hundred and three patients decrease their jaundice index successfully,58 patients decrease slowly,6 patients were failure to decrease;patients decreased successfully is superior to patients decreased slowly in the rate of tumor resection,incidience of complications and hospitalization time.To decreased successfully ones,the group accepeted surgery operation after 2 weeks’ drainage was not significantly to group of 3 weeks in tumor resection rate and incidence of complications.To decreased slowly ones,the bleeding volume during the radical surgery operation of the group who were drainged more than 3 weeks’was more significantly than the group less than 2 weeks,but tumor resection rate and the incidence of complications was no significant difference.To failure decreased ones, they have no choice to accepet the endodrainage surgery,however,after 1 month the average total bilirubin was at 252.8 mol/L,2 cases were dead. Conclusion:The jaundice index descending rate can be chosen as the standard of the operation opportunity,the continuous 2 weeks for total serum bilirubin decreasing rate of ≥ 30%,patiens may be able to proceed surgery;instead,they should be appropriately extended the drainage time.

    Treatment of biliary tract disease caused by clonorchiasis in nonendemic area
    LI Hang-yu,YU Yun,HE Jing-ni,et al.
    2007, 27(10): 1-823. 
    Abstract ( )   PDF (293KB) ( )  

    Objective:To assess clinical features and therapy of biliary tract emergency caused by clonorchiasis in nonendemic area. Methods:To retrospectively analyze 21 cases with biliary tract disease caused by clonorchiasis from January 1998 to April 2007. Results:Five of 21 cases were diagnosed definitely and treated by ENBD or EST.Others were diagnosed during the operation with cholecystectomy for 7 cases,choledocholithotomy for 6 cases,Choledochal jejunum RouXenY anastomosis for 2 and pancreaticoduodenectomy for 1.Prosopon and/or spawn were detected in bile. Conclusion:Etiological diagnosis is very important for the patient with biliary tract emergency in nonendemic area.Clonorchiasis has representative history and auxiliary examination results.Once diagnosed,surgery is necessary and deworming treatment should be taken.

    Laparoscopic radiofrequency ablation in the treatment of special site hepatocellular carcinoma
    DENG Mei-hai,HU Kun-peng,LI Kai,et al.
    2007, 27(10): 1-828. 
    Abstract ( )   PDF (282KB) ( )  

    Objective:To investigate the efficacy of laparoscopic radiofrequency ablation (LRFA) in the treatment of special site hepatocellular carcinoma. Methods:Twenty selected cases with HCC (with special site) were divided into two groups:LRFA group(Group A,n=11) and percutaneous radiofrequency ablation (PRFA) group (Group B,n=14). e observed the change of tumor area by ultrasonic visualization,preoperative and postoperative complications and follow up curative effect. Results:The difference of area change caused by operation between Group A and Group B was not significantly.There were less complications of injury of diaphragmatic muscle,bulk pleural effusion and incomplete rate of ablation.It found recurring cases in both groups. Conclusion:LARF in the treatment of special site hepatocellular carcinoma shows superiority and widening the cure extent of radiofrequency ablation.

    Surgical experience on biliary restricture after Roux-en-Y hepaticojejunostomy for bile duct injury
    DING Jia-zeng,PENG Cheng-hong,YAN Ji-qi,et al.
    2007, 27(10): 1-818. 
    Abstract ( )   PDF (448KB) ( )  

    Objective:To discuss the operation timing and methods of biliary restricture after Roux-en-Y hepaticojejunostomy for bile duct injury. Methods:From November 2005 to October 2006,seven cases of biliary restricture after Roux-en-Y hepaticojejunostomy for bile duct injury were admitted into Department.of Surgery,Ruijin Hospital,Medical School of Jiaotong University.The clinical data were analyzed retrospectively. Results:All these bile duct injuries were caused by cholecystectomy,six cases were laparoscopic cholecystectomy and one case was miniincision choleystectomy.According to the classification of Strasberg,one case was E1,three cases were E2,two cases were E3 and one case was E4.Six patients were performed Roux-en-Y hepaticojejunostomy again,and one of them received right hepatectomy afterward,and the remaining one patient received external biliary drainage.All these patients recovered fairly well. Conclusion:Roux-en-Y hepaticojejunostomy is still the main approach for bile duct injury repairment.For those complicated cases,the optimal timing and method of operation,the meticulous and excellent surgical skills are keys to success.

    Endovascular stent graft repair of stanford type A aortic dissection with the tear located the distal end of the aortic arch
    CHANG Guang-qi,WANG Shen-ming,LI Xiao-xi,et al.
    2007, 27(10): 1-828. 
    Abstract ( )   PDF (2515KB) ( )  

    Objective:To summarize clinic experience about Stanford type A aortic dissection with the tear located the distal end of the aortic arch treated by aortic endovascular repair (EVR) of stentgraft. Methods:Elected femoral artery approach,twentyone patients with the tear in the intima located the distal end of the aortic arch and the proximal end of the descending aorta were performed aortic EVR.And whether the LSA need to be reestablished or not by vertebral arteriography would be determined. Results:All patients (n=21)of the whole group were undergone EVR of stentgraft successfully,including acute dissection (n=13) and chronic dissection (n=8).Seventeen patients were undergone EVR with closing the LSA and 4 of them were reestablished the LSA.4 patients had endoleak and 1 patient had an incident of cerebral infarction after EVR.During the follow up at a mean 22.3 months (range,6-65 months),all patients were survival.CTA showed complete thrombosis of the false lumen occurred in 9 patients and part thrombosis of the false lumen occurred in 12 patients. Conclusion:Aortic endovascular stentgraft repair is an effective and safe treatment for Stanford type A aortic dissection with the tear located the distal end of the aortic arch and the proximal end of the descending aorta.This method has minimal invasion,high successful rate and few complications and so on.

    Evaluation of osteopontin as serum tumor marker for pancreatic cancer
    YANG Ying-Chi,ZHAO Yu-Pei,LIAO Quan,et al.
    2007, 27(10): 1-828. 
    Abstract ( )   PDF (2358KB) ( )  
    Objective:To evaluate the effect of osteopontin (OPN) as serum tumor marker on the diagnosis of pancreatic cancer. Methods:Used ROC(receiveroperating characteristics)curve methods to assay the serum content of OPN,CA19-9 and CA242 in 46 patients of the pancreatic cancer,18 patients of the chronic pancreatitis detected by enzymelinked immunosorbent assay (ELISA),and analyzed the results with statistics methods. Results:The serum levels of OPN,CA19-9 and CA242 in pancreatic cancer are all higher than in chronic pancreatitis respectively (P<0.001).To treat the measure results of four serum tumor markers with ROC curve methods,The AUC (area under curve) of OPN,CA19-9 and CA242 are 0.788,0.808 and 0.737,respectively.Subgroup analysis indicated that the OPN and CA19-9 levels for patients with resectable pancreatic cancer were lower than those for patients with unresectable pancreatic cancer (P<0.001). Conclusion:In diagnosis of pancreatic cancer,the clinical value of OPN is available.And the combination test of CA19-9 and OPN have clinical value to evaluate if the pancreatic cancer can be resected before operation.
    Investigation of Microincision in the treatment of osteofascial compartment syndrome
    RAN Feng,LIU Chang-jian,HUANG Dian,et al.
    2007, 27(10): 1-765. 
    Abstract ( )   PDF (1734KB) ( )  
    Objective:To investigate the therapeutic effect of microincision in the treatment of osteofascial compartment syndrome. Methods:The clinical data of 37 patients with osteofascial compartment syndrome caused by reperfusion injury after embolectomy admitted between February 1992 and July 2005 were analyzed retrospectively.All patients were performed open decompression operation on the legs with microincision.At the same time,the patients were given dehydration,diuresis drugs.The wounds were deferred the suturation time. Results:Among the 37 patients,33 patients were fully recovered.Two patients had toes mortification and got toe amputation operation.Two patients had sensory disability on legs and got recovered after trophic nerve medicine treatment three months later.No patient got ischemia muscle spasm or high amputation.The microincision got secondary suture in 22 patients and selfcure in 15. Conclusion:The therapeutic effect of microincision in the treatment of osteofascial compartment syndrome caused by reperfusion injury is satisfactory.Its forte is slight injury,small wound surface,little loss of extracellular fluid and protein,low probability of infection;selfcure in part of the microincision,no need of dermatoplasty.
    临床研究生园地
    Impact of growth hormone on cell cycle kinetics of inoculated pancreatic tumor,plasma IGF1 and mucous membrane of small intestine
    SHI Yi,ZHAO Yu-pei,LIAO Quan,et al.
    2007, 27(10): 1-828. 
    Abstract ( )  
    Objective:To evaluate the effect of growth hormone (GH) on the features of cell cycle of pancreatic tumor in vivo,plasma IGF1 and mucous membrane of small intestine. Methods:Fifty-three female Balb/c mice were inoculated with SW1990 cells.When tumors became palpable after inoculation, animals were randomized to receive GH (a.Group A,4mg/kg.s.c.once daily for 2 weeks;b.Group B,2mg/kg.s.c.for 2 weeks;c.Group C,2mg/kg.s.c.for 3 weeks.) versus saline control. At the time the animals were killed,tumors tissues were made into single cell suspensions for cell cycle evaluation.At the same time,such special specimens as tumor and small intestine were rapidly incised for subsequent observation using electron microscopy.Plasma was stored at -80℃ for subsequent IGF1 levels determination with ELISA techniques. Results:GH did not change the percentage of G1,G2M or S phase of pancreatic tumor cell in vivo.GH elevated level of plasma IGF1.Microstructure observation revealed active functional status in absorptive cell and goblet cell on experimental group. Conclusion:GH did not affect proliferation features of pancreatic tumor in vivo;as certain of anabolic effect, the ultrastructure of mucous membrane of small intestine was better preserved by GH administration.