Objective:To investigate the best operation opportunity of the malignant obstructive jaundice patients accepted the treatment of decrease their jaundice index before surgery. Methods:One hundred and sixtyseven cases of malignant obstructive jaundice patients were accepted percutaneous transhepatic biliary drainage by ultrasonic guidance, analysis their jaundice index descending rate ,tumor resection rate, incidence of complication. Results:One hundred and three patients decrease their jaundice index successfully,58 patients decrease slowly,6 patients were failure to decrease;patients decreased successfully is superior to patients decreased slowly in the rate of tumor resection,incidience of complications and hospitalization time.To decreased successfully ones,the group accepeted surgery operation after 2 weeks’ drainage was not significantly to group of 3 weeks in tumor resection rate and incidence of complications.To decreased slowly ones,the bleeding volume during the radical surgery operation of the group who were drainged more than 3 weeks’was more significantly than the group less than 2 weeks,but tumor resection rate and the incidence of complications was no significant difference.To failure decreased ones, they have no choice to accepet the endodrainage surgery,however,after 1 month the average total bilirubin was at 252.8 mol/L,2 cases were dead. Conclusion:The jaundice index descending rate can be chosen as the standard of the operation opportunity,the continuous 2 weeks for total serum bilirubin decreasing rate of ≥ 30%,patiens may be able to proceed surgery;instead,they should be appropriately extended the drainage time.