Abstract: Pharmacological treatment of chronic venous diseases of the lower extremities        ZHAO Jun. Department of Vascular Surgery, the Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Abstract    Chronic venous diseases(CVDs)of the lower extremities are the most common vascular diseases that affect the physical health of adults. Even the symptoms are relatively mild, due to the symptoms and signs usually existing all year round, one’s work efficiency could be reduced, and the quality of life doomed to be affected, consequently. In recent decades, some venoactive drugs(VADs)extracted from plants and some synthetic drugs were developed. They have the efficacy of antioxidant, and anti-inflammatory, protecting the function of vascular endothelial cells, maintaining venous tone, reducing venous leakage, increasing venous or lymphatic flow, and indicate confirmed effects on releasing pain, swelling, heaviness, cramps, leg restlessness, and other symptoms, as well as edema, skin sclerosis, ulcers and other signs of the CADs. The main drugs are micronized purified flavonoids, Ruscus extract, horse-chestnut extract, French maritime pine bark extract, red vine leaf extract, rutin, calcium dobesylate, etc. Pentoxifylline, one of the vasoactive drugs, and Sulodexide, as the vascular endothelial cell stabilizer, also have definite venous active effects, and they are also recommended for the management of CVDs.

Key words: chronic venous diseases, venoactive drugs

摘要： 下肢慢性静脉病（CVD）是影响成年人身体健康的最常见血管病之一，即使症状相对轻微，因为症状和体征常年存在，影响工作效率，最终影响生活质量。近几十年来，研发了许多源自植物成分以及部分人工合成的静脉活性药物（VAD），具有抗氧化、抗炎、保护血管内皮细胞功能、维持静脉张力、减少静脉渗漏、增加静脉和淋巴回流的功效，对慢性静脉病的疼痛、胀感、沉重、痉挛、腿不宁等症状，以及水肿、皮肤硬化、溃疡等体征，有明确的治疗效果。主要有微粒化纯化黄酮、假叶树提取物、马栗子提取物、法岸松提取物、红藤叶提取物、芦丁、羟苯磺酸钙等。血管活性药物几酮可可碱与血管内皮稳定剂舒洛地特也具有明确的静脉活性作用，因而也获得在慢性静脉病方面的推荐应用。

关键词: 慢性静脉病, 静脉活性药物