Abstract: Therapeutic strategies for metastatic pancreatic neuroendocrine tumors        LOU Wen-hui. Department of Pancreatic Surgery，Zhongshan Hospital，Fudan University，Shanghai 200032，China
Abstract    The incidence of pancreatic neuroendocrine tumors is increasing over the years，about 30%-40% is metastatic disease. When treatment strategy，lots of factors need to be considered，tumor grade，primary tumor sire，hepatic tumor burden，whether there is extrahepatic lesion，Whether the tumor is sporadic or familial，functioning or nonfunctioning，patient's age and performance status. Taking the long-term survival and improvement of the quality of life of the patient as the treatment goal，comprehensively adopt surgery，drugs and other treatment measures.

Key words: pancreatic neuroendocrine tumors, liver metastasis, treatment

摘要： 胰腺神经内分泌肿瘤的发病率逐年增加，其中30%~40%为肝脏转移性肿瘤。在制定治疗方案时，须综合考虑肿瘤的分级、原发灶部位、肝转移灶肿瘤负荷、是否有肝外转移、肿瘤是散发性或家族性、功能性或无功能性肿瘤、病人年龄和体能状态等诸多因素，以病人的长期生存和生存质量的改善为治疗目标，并综合采用手术、药物等治疗措施。

关键词: 胰腺神经内分泌肿瘤, 肝转移, 治疗