Abstract: Application of photodynamic therapy in cholangiocarcinoma       ZHOU Liu-xin*,ZENG Jiang-chao, YU Wen-hao,et al.  *Department of Hepatopancreatobiliary Surgery, the Affiliated Hospital of Qinghai University, ,Xining 810001,China；Qinghai Provincial Research Key Laboratory for Hydatid, Xining 810001, China；Department of Hepatopancreatobiliary Surgery,the Affliated Fuling Hospital of Chongqing University,Fuling 408000,China
Corresponding authors：WANG Zhi-xin，E-mail:zhixin_wang001@
sina.com；REN Li,E-mail:renli_01@126.com
ZHOU Liu-xin and ZENG Jiang-chao are the first authors who contributed equally to the article.
Abstract    The early diagnosis of cholangiocarcinoma is very difficult, and most patients have lost the opportunity for operation at the time of initial diagnosis. The median survival time of patients with cholangiocarcinoma without intervention was no more than 3 months. For patients with cholangiocarcinoma who can not accept R0 resection, a reasonable biliary drainage strategy is an important factor affecting the quality of life and prognosis. After the intervention measures such as the surgical establishment of biliary intestinal bypass drainage, biliary stent, and percutaneous transhepatic biliary drainage, foreign countries have focused on the application of photodynamic therapy in the palliative treatment of cholangiocarcinoma. Photodynamic therapy has been used abroad as a common palliative treatment for unresectable cholangiocarcinoma due to its advantages of less invasiveness, less postoperative complications, less toxic side effects of photosensitizers, reproducibility of treatment and higher lesion selectivity.

Key words: cholangiocarcinoma, endoscopic therapy, photodynamic therapy, photosensitizer

摘要： 胆管癌的早期诊断十分困难，大部分病人在初次确诊时已失去手术机会。而未经干预的胆管癌病人，中位生存时间不超过3个月。对于无法接受根治性手术切除的胆管癌病人，合理的胆道引流策略是影响病人生存质量及预后的重要因素。经历过手术建立胆肠旁路引流、胆道支架内引流、经皮肝穿刺胆道外引流等干预措施后，国外已将目光聚集于光动力治疗在胆管癌姑息性治疗中的应用。由于光动力治疗具有治疗创伤性小、术后并发症轻、光敏药物毒副反应少、治疗可重复性强、病灶选择性高等优点，国外已将光动力治疗作为不可切除胆管癌的常用姑息性治疗手段。

关键词: 胆管癌, 内镜治疗, 光动力治疗, 光敏剂