Abstract: Introduction to the JLSSG0901 results        Yukinari Tokoro.Department of Digestive Surgery, Affiliated  Hospital, Medicine and Faculty of Medicine Kyoto University, Kyoto， Japan
Abstract    JLSSG0901 is a large-scale clinical study of laparoscopic-assisted and open distal gastrectomy for advanced gastric cancer in Japan. With the presentation of phaseⅡresults of the study in 2015, Japanese scholars believed that the results of the CLASS01 trial in China and the KLASS02 trial in Korea were not applicable to Japan due to insufficient evidence, and it was unsuitable to recommend laparoscopic surgery for advanced gastric cancer in Japan. Therefore, the 6th edition of Japanese gastric cancer treatment guideline did not make specific recommendations for laparoscopic surgery for advanced gastric cancer. The phase III results (long-term results) of JLSSG0901, which demonstrated the non-inferiority of laparoscopic-assisted distal gastrectomy in the treatment of advanced gastric cancer in Japan, were presented at the 94th Annual Meeting of the Japanese Gastric Cancer Association in march 2022, attracting much attention of Japanese scholars. This result may lead to the expansion of indications for laparoscopic gastrectomy in revising the 7th edition of Japanese gastric cancer treatment guideline.

Key words: stomach neoplasms, laparoscopy, gastrectomy

摘要： JLSSG0901是日本关于进展期胃癌行腹腔镜与开放远端胃切除术的大规模临床研究。自2015年该研究的Ⅱ期结果发布后，由于没有足够的证据，日本学者认为尚不能将中国的CLASS-01和韩国的KLASS-02研究结果延用至日本，以及不适合在日本对进展期胃癌病例推荐腹腔镜手术治疗，故第6版日本《胃癌治疗指南》未对进展期胃癌的腹腔镜手术治疗提出明确建议。在2022年3月第94届日本胃癌学会年会上公布了该项研究的Ⅲ期结果（长期结果），引起日本学者广泛关注。目前公布的Ⅲ期结果证明了腹腔镜远端胃切除术在治疗日本进展期胃癌病例中的非劣效性。该结果可能会导致在第7版日本《胃癌治疗指南》修订中腹腔镜胃切除术的适应证扩大。

关键词: 胃癌, 腹腔镜, 胃切除术