Abstract:

Analysis of correlative factors for extrathyroidal extension in papillary thyroid carcinoma        SONG Yun-tao, YU Wen-bin, WEI Wei, et al. Department of Head and Neck Surgery, Peking University Cancer Hospital；Research Institute for Prevention and Treatment of Tumor of Beijing; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China
Corresponding author: SONG Yun-tao, E-mail：32827682@qq.com
Abstract    Objective    To analyze the correlative factors for extrathyroidal extension (ETE) in papillary thyroid carcinoma. Methods    The medical records of 1642 consecutive patients with papillary thyroid carcinoma (PTC) admitted between January, 2014 and December, 2015 in Peking University Cancer Hospital were analyzed retrospectively. Patients’gender, age, size of tumor, multicentricity, state of lymph node metastasis, preoperative biopsy and combining with Hashimoto's thyroiditis were investigated for assessment of the correlative factors associated with ETE. Results    A total of 1004 patients （61.1%） had ETE. Multivariate analysis revealed that major diameter of tumor more than 1 cm（OR=3.789，95%CI 3.012-4.768，P<0.001），multicentricity （OR=1.848，95%CI 1.445-2.362，P<0.001）and 55 age and older （OR=1.331，95%CI 1.003-1.767，P=0.047）were independent risk factors for ETE in papillary thyroid carcinoma. Conclusion    ETE in papillary thyroid carcinoma is associated with characteristics such as larger tumor, multicentricity and advanced age. ETE should be taken notice of in patients with clinicopathological characteristics.

Key words: thyroid carcinoma, extrathyroidal extension, papillary carcinoma, prognosis

摘要：

目的    分析甲状腺乳头状癌术后病理学腺外侵犯的相关因素。方法    回顾性分析2014年1月至2015年12月北京大学肿瘤医院头颈外科收治的甲状腺乳头状癌初治连续病例1642例资料，统计病人性别、年龄、肿瘤大小、单发或多发、淋巴结转移、术前穿刺及伴有桥本甲状腺炎等临床病理学特征，比较其与术后病理学腺外侵犯的关系。结果    共有1004例病人伴有腺外侵犯（61.1%）。多因素分析显示：肿瘤长径>1 cm（OR=3.789，95%CI 3.012～4.768，P<0.001），多发病灶（OR=1.848，95%CI 1.445～2.362，P<0.001），年龄≥55岁（OR=1.331，95%CI 1.003～1.767，P=0.047）是甲状腺乳头状癌腺外侵犯的独立危险因素。结论    甲状腺乳头状癌的腺外侵犯与肿瘤较大、多发病灶、高龄等因素相关，具有以上临床病理学特征的病人应警惕腺外侵犯的发生。

关键词: 甲状腺癌, 腺外侵犯, 乳头状癌