Abstract:

Multicentric Castleman's disease: A clinical analysis of 16 patients        YANG Hua-wu*, LI Xu-guang, ZHAO Hai-ying. *Department of General Surgery, Third People’s Hospital of Chengdu, Chengdu 610000, China
Corresponding author: ZHAO Hai-ying, E-mail:zhao0302@hotmail.com
Abstract    Objective    To investigate the clinical manifestation, diagnosis and treatment of multicentric Castleman's disease. Methods    The diagnosis, treatment and prognosis of 16 patients with multicentric Castleman's disease diagnosed by pathology in Shengjing Hospital of China Medical University from August 2008 to October 2016 were analyzed retrospectivley. Results    The 16 patients included hyaline vascular type (HV,50%), plasma cell type (PC,37%), mixed variant type (Mix,13%). Among the 9 cases of follow-up data available, 7 cases achieved complete remission ( HV 5，PC 2), 2 lived with disease (HV) , and no patients died. The follow-up rate was 56%, while the median follow-up time was 22 months. Conclusion    Multicentric Castleman's disease involves multiple systems and organs, and clinical performance, physical and chemical inspection guidance are not obvious, which lead to missed diagnosis and misdiagnosis easily. Accurate diagnosis and intervention of multicentric Castleman’s disease with varied performance is crucial and a histopathological evaluation of an excised specimen is recommended, especially the lymph nodes biopsy. The multicentric type is treated mainly by surgery, assisted by chemotherapy and other ways, which all above leads to a systematic treatment.

Key words: Castleman's disease, pathology

摘要：

目的    探讨多中心型Castleman病的临床表现、诊断及治疗方法。方法    回顾性分析2008年8月至2016年10月中国医科大学附属盛京医院经病理学检查确诊的16例多中心型Castleman病的诊疗过程及预后。结果 本组16例病人病理学分型组成为透明血管型（HV）50%、浆细胞型（PC）37%、混合型（Mix）13%。随访9例，随访率56%，中位随访时间为22个月，完全缓解7例（HV 5例，PC 2例），带病生存2例（均为HV）；无死亡病例。结论    多中心型Castleman病常累及多个系统及器官，临床表现、影像学及实验室检查无特异性，易漏诊及误诊。早期诊断、治疗是关键，确诊依靠病理学检查，治疗主要以手术为主，辅以化疗等系统治疗。

关键词: Castleman病, 病理学