Abstract:

Effect of Roux-en-Y gastric bypass on body metabolism in non-obese type 2 diabetes mellitus rates        ZHANG Xiong *, YU Bo，WANG Ting-feng, et al. * Center for Metabolic and Bariatric Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China
Corresponding author: ZHANG Peng, E-mail：zhangpg@yahoo.com
Abstract    Objective    To investigate the whole body metabolism in non-obese type 2 diabetes mellitus rats after Roux-en-Y gastric bypass (RYGB) surgery. Methods    Non-obese Goto-Kakizaki (GK) rats were randomized into two groups according to the surgical procedure performed including 1) RYGB (n=10), 2) Sham surgery (n=10). In addition, age-matched Wistar rats were employed as normal non-diabetic controls. Fasting plasma glucose and body weight were measured in vivo before and 2, 4, and 8 weeks after the surgery. Activities and metabolic rate of all rats were monitored by metabolic cage system postoperatively. Results  Comparing with normal control rats and Sham group, after RYGB surgery, the body weight (P<0.0001), food intake (P<0.0001), fasting plasma glucose (P<0.0001), and free activities at night (P<0.01) were all significantly lower. However the metabolic rate was increased at day (P<0.01) and night (P<0.01). Conclusion    RYGB can improve glucose metabolism in non-obese type 2 diabetes mellitus via the mechanism of promoting the overall body metabolism.

Key words: bariatric surgery, Roux-en-Y gastric bypass, non-obese type 2 diabetes mellitus, metabolic rate

摘要：

目的    探讨Y型胃旁路术（RYGB）对非肥胖型2型糖尿病（T2DM）大鼠整体代谢水平影响及其意义。方法    将20只非肥胖型T2DM Goto-Kakizaki（GK）大鼠随机分为RYGB手术组和假手术组（Sham），另取10只健康Wistar大鼠设为正常对照。检测术前以及术后2、4、8周大鼠体重、摄食量和空腹血糖变化，并利用大鼠实时代谢检测系统监测各组大鼠术后整体代谢变化。结果    与正常对照组以及Sham组相比，RYGB术后大鼠体重显著降低（P<0.0001），摄食量减少（P<0.0001），空腹血糖明显减低（P<0.0001），夜间活动量减少（P<0.01），全天候代谢率均增加（P<0.01）。结论    RYGB手术可改善非肥胖型T2DM的血糖调节，可能与该手术后机体代谢水平提高有关 。

关键词: 减重手术, Y型胃旁路手术, 非肥胖型2型糖尿病, 代谢率