Abstract:

Several hot issues of neoadjuvant chemotherapy for breast cancer        WANG Wei, WU Jia-yi, SHEN Kun-wei. Breast Disease Center, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Corresponding author: SHEN Kun-wei, E-mail: kwshen@medmail.com.cn
Abstract    Neoadjuvant chemotherapy provides clinical outcomes equivalent to those achieved from adjuvant setting. The therapeutic response to neoadjuvant treatment may include a reduction in tumor burden that alleviates the morbidity associated with locoregional therapy. Important prognostic information can be gained based on the response to treatment and knowing the quantity and biology of the residual disease. Landmark trials and contemporary perspectives on neoadjuvant treatment regimens are the issues that surgeons should grasped and pay attention to. The standard neoadjuvant chemotherapy could improve the survival of patients with breast cancer.

Key words: breast cancer, neoadjuvant treatment

摘要：

新辅助治疗可以为病人带来与辅助治疗相似的临床获益。新辅助治疗能够降低肿瘤负荷，从而使手术范围缩小，手术创伤减小。研究肿瘤对新辅助治疗的反应性可以获得重要的预后信息，更好地了解残余肿瘤的生物学行为。乳腺癌新辅助治疗方案的选择、新辅助治疗后手术及放疗的决策是临床医师应掌握和重视的问题。对乳腺癌病人实施规范化的新辅助治疗将有助于提高生存获益。

关键词: 乳腺癌, 新辅助治疗