Abstract:

Updates and interpretations of the NCCN Clinical Practice Guidelines 2015 on hepatocellular carcinoma                LIU Lian-xin, LI Ke-yu. Hepatic Surgical Ward of the First Affiliated Hospital of Harbin Medical University, Harbin 150001,China
Corresponding author:LIU Lian-xin, E-mail: liulianxin@medmail.com.cn
Abstract    The updates of NCCN clinical practice guidelines in oncology 2015 V1 on liver cancer include: ultrasound was updated to the primacy as a screening tool; in the part of surgery, the guidelines mentioned that there were controversies about those patients whose tumor characteristics are marginally outside of the UNOS criteria and may be considered for liver transplantation, furthermore, patients with tumor characteristics beyond Milan criteria that are downstaged to within criteria can also be considered for transplantation; the priority of locoregional therapy was recommended in inoperable patients and TARE, IMRT and PBT were updated. NCCN clinical practice guidelines in oncology offer sufficient information for clinic, but due to the difference of race and region and the heterogeneity of tumor, the new updates would go better through the clinical practice.

Key words: hepatocellular carcinoma (HCC), National Comprehensive Cancer Network (NCCN), intensity-modulated radiation therapy (IMRT), proton beam therapy (PBT)

摘要：

2015年肝脏肿瘤V1版美国国立综合癌症网络(NCCN）指南变更重点包括：在肝细胞癌的筛查中明确了超声检查作为首选方式的重要性；外科手术部分提出了对于略超出美国器官共享网络移植标准的病人可以考虑肝移植；此外，超出米兰标准但降期治疗后符合标准的病人也可考虑移植；强调局部治疗在非手术治疗方式中的重要性并更新经动脉放射栓塞（TARE）、调强放射疗法（IMRT）及质子束疗法（PBT）等治疗手段。NCCN临床实践指南为临床提供了借鉴，由于种族不同、地域有别以及肿瘤的异质性，更新后的标准需要接受临床实践的检验才能达到进一步完善。

关键词: 肝细胞癌, 美国国立综合癌症网络, 调强放射疗法, 质子束疗法