Abstract:

Objective:To investigate the role of arachidonic acid metabolism in Crohn’s disease complicated by intestinal fistula. Methods:By immunohistochemical methods, we examined the expression pattern of major arachidonic acid metabolizing enzymes in 17 samples of Crohn;s disease with associated intestinal fistula. Results:Arachidonic acid metabolizing enzymes were universally present in Crohn’s disease intestines,and the spatial distribution of cyclooxygenase2,5lipoxygenase and 15lipoxygenase1 expression followed sequential arrangement in Crohn’s ulcer. Conclusion:The regulated distribution of these enzymes indicated protective roles for cyclooxygenase 2 and 15lipoxygenase1 and deleterious roles for 5lipoxygenase in Crohn’s disease.

Key words: s disease, Arachidonic acid metabolism；Cyclooxygenas；Lipoxygenase, Crohn&rsquo

摘要：

目的:探讨花生四烯酸代谢在克罗恩病并发肠瘘病理机制中的作用。方法:通过免疫组化考察花生四烯酸代谢的主要酶系在17例克罗恩病并发肠瘘的病变肠组织的表达情况。结果:花生四烯酸代谢酶广泛表达于克罗恩病肠组织，其中环氧化酶-2，5-脂氧化酶和15脂氧化酶在克罗恩病溃疡部位的表达形成了规律性的空间分布。结论:环氧化酶-2和15-脂氧化酶是克罗恩病炎症消退和组织修复的关键成分，而5脂氧化酶可能是克罗恩病炎症放大的动力。

关键词: 克罗恩病, 花生四烯酸代谢, 环氧化酶, 脂氧化酶