To evaluate the clinical utility of a single-hand-operable hepatic pedicle clamp in laparoscopic hepatectomy and analyze its impact on surgical workflow optimization and postoperative outcomes. Methods    A retrospective analysis was conducted on the clinical data of 43 patients who underwent laparoscopic liver tumor resection at the First Affiliated Hospital of Wannan Medical College between March 2019 and February 2023. The hepatic pedicle clamp, self-developed for single-hand operation, was used for intermittent occlusion of the first hepatic portal during surgery. Key recorded metrics included occlusion time, operative time, intraoperative blood loss, postoperative hospital stay, and complication rates. Results    All procedures were successfully completed without conversion to open surgery. The hepatic pedicle clamp enabled effective intermittent occlusion of blood flow to the first hepatic portal (15 minutes of occlusion followed by 5 minutes of release), with a median occlusion frequency of 4 times and a median occlusion time of 60 minutes. The mean operative time was (318.1±113.6) minutes, the mean intraoperative blood loss was (535.1±395.5) mL, and the mean postoperative hospital stay was (8.2±4.1) days. The postoperative complication rate was 11.6%, all classified as Clavien-Dindo grade I or Ⅱ. No grade Ⅲa or higher complications or mortality were observed. Additionally, no postoperative portal vein thrombosis or hepatic artery aneurysm occurred in any patient. Conclusion    The single-hand-operable hepatic pedicle clamp is simple to use, facilitates workflow optimization in laparoscopic hepatectomy, and reliably achieves hepatic portal blood flow occlusion. Its use significantly reduces intraoperative blood loss and postoperative complications. This device offers a safe, effective, and convenient tool for laparoscopic hepatectomy and holds significant potential for widespread clinical applications.