Expression of c-myc in triple negative breast cancer and its relationship with recurrence and metastasis                      ZENG Jian-feng*, QIU Cheng-zhi, ZHOU Zhi-ping, et al. *Department of General Surgery, the Second Affiliated Hospital, Fujian Medical University, Quanzhou 362000,China
Corresponding author: ZENG Jian-feng, E-mail: bbjian@gmail.com
Abstract    Objective    To explore the c-myc protein expression in triple negative breast cancer and its relationship with recurrence and metastasis. Methods    C-myc expression of 157 cases of women TNBC underwent surgery, 30 cases of non-TNBC and 20 cases of normal breast tissue paraffin samples admitted between January 2005 and April 2008 in the Second Affiliated Hospital of Fujian Medical University（98 cases of TNBC, 20 cases of non-TNBC and 10 cases of normal samples） and Changji Hui Autonomous Prefecture People's Hospital of Xinjiang Uygur Autonomous Region（59 cases of TNBC, 10 cases of non-TNBC and 10 cases of normal samples） were analyzed retrospectively. Results    Positive rate of c-myc expression in TNBC was higher than that of non-TNBC and that of normal breast with significant difference (P＜0.005). Univariate analysis showed that TNM stage, histological grade, axillary lymph node metastasis, postoperative recurrence and metastasis were the related factors of c-myc expression (P＜0.05). Logistic regression analysis showed that TNM staging was not the influential factors of c-myc expression （OR=2.243，P=0.073）. Univariate analysis of affected disease-free survival time showed that age, clinical stage, histological grade, axillary lymph node metastasis and c-myc expression had relationship with recurrence and metastasis of TNBC (P＜0.05). Multivariate clinical staging and c-myc expression were excluded. Conclusion    C-myc may be an influential factor of postoperative recurrence and metastasis of triple negative breast cancer, but be not an independent risk factor. C-myc expression can be used as one of indicators of progression and malignant degree of TNBC.