CXCR4 to clinically distinguish malignant biliary obstruction from benign biliary obstruction        LIN Ke-yu，SU Hua-wei. Department of General Surgery，the Second Affiliated Hospital of Harbin Medical University，Harbin 150086，China
Correspongding：SU Hua-wei，E-mail：Shw@medmail.com.cn
Abstract    Objective    Aim of the study was to investigate the value of bile and serum chemokine receptor-4（CXCR4) for distinguishing malignant biliary obstruction from benign biliary obstruction. Methods    Selected 44 cases of obstructive jaundice patients treat in the second affiliated hospital of Harbin medical university in February 2013 to June，including 21 cases of malignant biliary obstruction，23 cases of benign biliary obstruction. Their sera and bile were collected to detect the CXCR4 concentration by using enzyme-linked immunosorbent method, and conventional testing other biochemical indexes: hemoglobin(Hb)，total bilirubin，direct bilirubin，alkaline phosphatase(ALP)，alanine aminotransferase(ALT)，aspartate aminotransferase(AST)，γ-glutamine transferase ammonia(GGT). Do a statistical analysis of the index difference of benign and malignant biliary obstruction patients. Results    We can found that age，sex，hemoglobin，ALT，AST，ALP had no significant value between the benign and malignant biliary obstruction (P>0.05). However，r-GT，total bilirubin，serum CXCR4，bile CXCR4 had statistical significance (P<0.05). The result of multiple regression analysis show that the 5 indicators which enriched in the regression analysis，only the bile CXCR4 had relationship with benign and malignant biliary obstruction (OR=1.05，95%CI 1.04~1.06，P<0.05). Conclusion  Measurement of biliary CXCR4 may differentiate malignant biliary from benign biliary strictures，and for the clinical differential diagnosis has a reference value.