Application of ultrasound-guided fine-needle capillary cytology in diagnose of thyroid nodules：A report of 350 cases        ZHOU Le,ZHANG Guang, HAN Jing,et al. Department of Thyroid Surgery, China-Japan Union Hospital, Jilin University，Changchun 130033,China
Corresponding author:SUN Hui, E-mail:sunhui1229@163.com
Abstract    Ojective    To investigate the technique and method to improve the successful rate of thyroid nodule puncture biopsy. Method    We used ultrasound-guided fine-needle capillary cytology with multi-faceted pulling approach for thyroid nodule biopsy. The result was compared with post-operative paraffin pathological findings. Result  A total of 350 cases(394 thyroid nodules) with biopsy results were involved, in which specimen of 35 nodules (9%) can not be diagnosed or dissatisfied; in the rest,138 nodules of benign, 56 nodules of undetermined atypical cells lesions or follicular lesions, none of follicular or suspicious follicular neoplasm, 30 nodules of suspicious malignancy, and 135 nodules of malignancy(34%, 133 nodules of papillary carcinoma, 2 nodules of medullary carcinoma). Compared with post-operative histopathology findings of 159 nodules, the sensitivity and the specificity were 88% and 79%. After the first 50 cases were excluded for the effect of the learning curve, the sensitivity and the specificity reached to 93% and 76%. 7 cases occurred local tiny hematoma during operation .No serious complication occurred. Conclusion    The reformed ultrasound-guided fine-needle capillary cytology meets the requirements of drawing matieral and simply operating ; after a period of learning curve, the technology would help to significantly improve the diagnostic sensitivity of thyroid nodules.