Advance of chemotherapy and targeted therapy in colorectal liver metastases        SHEN Lin. Department of Gastroenterology, Peking University Cancer Hospital, Beijing 100142，China
Abstract    Advances in the treatment of colorectal liver metastases (CRLM) have benefited from the development of multidisciplinary treatment. But many problems are still unresolved in clinical practice including optimization of chemotherapy, advantages and disadvantages of combination of targeted therapy with chemotherapy, safety and chemotherapy timing, etc. Especially after the failure of CRLM adjuvant chemotherapy or targeted therapy, there is a growing concern about preoperative treatment and conversion therapy. Effective chemotherapy can provide more opportunities of radical resection and prolonged survival. Rational option of combination of targeted therapy with chemotherapy, correct chemotherapy duration and withdrawal time are the keys to improve management level of CRLM.