Expression and significance of interleukin-11(IL-11) and interleukin-11 receptor (IL-11R) in primary hepatic carcinoma        SUN Chuan-zheng*, HUANG Fei-zhou, YANG Ming-shi, et al. *Department of General Surgery, Third Affiliated Hospital, Central South University, Changsha 410013, China
Corresponding author: HUANG Fei-zhou, E-mail: zheng-1016@hotmail.com
Abstract    Objective    To clarify the role of  IL-11 and IL-11R in human hepatocellular carcinoma. Methods    Thirty primary hepatic carcinoma (PHC) tissues, their pericarcinomatous liver tissues and their clinicopathological factors admitted between December 2006 and March 2007 in the Third Affiliated Hospital, Central South University were obtained in the current study. Expression levers of IL-11 and IL-11R proteins in samples of pericarcinomatous liver and tumor tissue were analyzed by Western blot. The IOD of IL-11, IL-11R and β-actin was analyzed quantitatively by analysis software. The expression level of IL-11 and IL-11R was denoted by the ratio of IOD, which was called value A.  Results    The expression of IL-11 and IL-11R was upregulated obviously in PHC tissue. The expression of IL-11 was significantly related to Edmondson’s grade, capsule invasion and tumor’s thrombus in portal vein and the expression of IL-11R was correlated with Edmondson’s grad, capsule invasion and tumor’s thrombus in portal vein. Conclusion    The finding suggests that IL-11/IL-11R may play important role in the occurrence, differentiation, invasion and transfer of PHC.