Diagnosis and treatment of pancreatic cystic neoplasms：clinical analysis of 132 cases        ZHANG Tai-ping*, XIAO Jian-chun, CAO Zhe, et al. *Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China
Corresponding author: ZHAO Yu-pei, zhao8028@263.net
Abstract    Objective    To summarize the experience in diagnosis and treatment of pancreatic cystic neoplasms. Methods    The clinical data of 132 patients diagnosed with pancreatic cystic neoplasms treated in Peking Union Medical College Hospital from Jan 2009 to Feb 2013 were retrospectively analysis. Results    Spleen-preserving distal pancreatectomy, distal pancreatectomy, Beger procedure, Whipple procedure, tumor enucleation, segment resection, total pancreatectomy and biopsy were performed in 79, 10, 3, 15, 12, 7, 1, 5 Patients, respectively. No patient died within the perioperative period. Pancreatic fistula (B and C) occurred in 4 patients (3%), postoperative hemorrhage(B and C) occurred in 7patients (5.3%).All 22 patients in malignant group were followed up from 9 to 45 months. 2 patients died and the others survived without relapse and metastasis .The following factors including old age（P=0.029）, with clinical symptoms（P=0.024）, weight loss（P=0.019）, jaundice（P=0.021）, having solid component or nodule（P=0.015）, big size（P=0.043）, elevated serum CA19-9 and CEA（P=0.006，P=0.009）were significantly correlated with malignant cystic neoplasms of pancreas in univariate analysis. old age（P=0.043）and elevated serum CA19-9（P=0.048）were identified as independent predictive factors for malignancy by multivariate analysis. Conclusion    There is no specific symptom of pancreatic cystic neoplasms. Morphological study plays an important role in the diagnosis. Patients with clinical symptoms or highly suspected malignant lesion should be operated in accordance with tumor location, size, and relationship between pancreatic duct, as well as pathological features. The function of the pancreas should be preserved.