Study on clinicopathological features and prognostic factors in Borrmann type I gastric cancer        HUANG Bao-jun, XU Hui-mian. Department of Surgical Oncology, First Hospital of China Medical University, Shenyang 110001, China
Corresponding author: XU Hui-mian, E-mail: xuhuimian@126.com. 
Abstract    Objective    To study the clinicopathological features and prognostic factors in Borrmann type I gastric cancer. Methods    A retrospective analysis of gastric cancer database from 1980 to 2006, at the Department of Surgical Oncology, First Affiliated Hospital, China Medical University was performed. A total of 110 patients with Borrmann type I were selected, followed up and analyzed. Results    Among all the patients, 89 patients were male, 21 patients were female. 63 with tumor size more than 6.0 cm, 68 with massive or nested growth pattern. A total of 62 patients were with positive lymph node metastasis. According to 7th UICC/TNM stage, there were 21 patients in N1, 22 patients in N2, and 19 patients in N3. Twenty-three patients were in level I, 34 in level II, and 5 in leveal III/M based on JGC/N stage. Gender and lymphatic/venous invasion were independent factors on lymph node metastasis by uni- and multivariate analysis. Gender, depth of tumor invasion, radical degree and JGC node classification were the independent prognostic factors（P＜0.05）.  Conclusion    There are relatively independent clinicopathological features in Borrmann type I gastric cancer. The more lymph node metastasis and poorer prognosis are observed in female patients.