Study of Sapylin in the treatment of breast cancer in nude-mice model        WANG Yong-kun*， LU Yun-shu，WU Ke-jin，et al. *Department of General Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Corresponding author：WU Ke-jin，E-mail: kejinwu@163.com
Abstract    Objective    To evaluate the value of Sapylin in the treatment of breast cancer. Methods    On the basis of establishing an animal model of breast cancer, local injection of Sapylin was used to observe changes in tumor weight, tumor diameter and immune parameters. Thirty cases of breast cancer patients were performed treatment of Sapylin. The postoperative drainage, wound and blood changes in immune parameters were observed. Results    In the breast cancer model, the tumor inhibition rate of Sapylin is 32.48%, and the expressions of IL-6, IL-12 and TGF-βwere significantly improved compared with the control group. The drainage was reduced 20%-30% in the 5th day after operation, and wound recovery of clinical patients with treatment of Sapylin was in good condition. The CD4/CD8 turned from 2.23 to 1.74, which was to say that the immune system got right, and there was no improvement in the number of NK cell than patients without Sapylin. There was no apparent adverse reaction. Conclusion    Sapylin has nice efficacy in the treatment of breast cancer, and could enhance the anti-tumor immunity of the host.