Diagnosis and treatment of Paget disease of the breast               ZHANG Chi，DUAN Xue-ning. Breast Disease Center of Peking University First Hospital, Beijing 100034, China
Corresponding author：DUAN Xue-ning, E-mail：xuening666@126.com
Abstract    Paget disease of the breast is a rare disorder of the nipple-areola complex that is often associated with an underlying in situ or invasive carcinoma. The histogenesis of Paget disease of the breast continues to be debated. Routine preoperative assessment, including physical exam, mammography, ultrasonography and magnetic resonance imaging should accurately assess the extent of underlying cancer in patients with Paget disease of the breast. Magnetic resonance imaging is of great important. Mastectomy has been considered the standard of care in the management of patients with Paget disease of the breast. Nowadays, however, some patients with Paget disease of the breast are candidates for breast-conserving therapy. Patients must be selected carefully on an individual basis. Sentinel lymph node biopsy has a high accuracy and low false-negative rate in Paget disease and should be performed in all patients.