Diagnosis and treatment of soft tissue sarcomas: hot and difficult problems        WANG Ya-nong, CHEN Yong. Department of Gastric and Soft Tissue Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Corresponding author: WANG Ya-nong, E-mail: wangyn1111@hotmail.com
Abstract    Diagnosis and treatment of soft tissue sarcoma (STS) have evoked emphasis clinically with the incidence rate slightly increased recently. Despite various evidence-based medicine guidelines or strategies have been sponsored worldwide, misdiagnosis and mistreatment of STS, which would negatively impact further treatment and even patients' survival, are not uncommonly encountered. It's mandatory to obtain a histopathological diagnosis of STS by biopsy before definite treatment, but the importance of biopsy was underestimated and the methods of biopsy were not always rational. As to therapy, surgical resection remains the mainstay of treatment, but a multidisciplinary treatment model has been accepted due to the emerging evidences supporting the use of chemoradiotherapy and target therapies. The optimized individualized treatment should be performed for STS according to different subtypes.