To explore the efficacy of enteral nutrition therapy on enterocutaneous fistula of crohn’s disease        YAN Dong-sheng,REN Jian-an,HAN Gang,et al. School of Medicine; Nanjing University, Research Institute of General Surgery, Nanjing General Hospital of Nanjing Command, Nanjing 210002,China
Corresponding author: REN Jian-an，E-mail：jan@medmail.com.cn
Abstract    Objective    To investigate the efficacy of enteral nutrition (EN) therapy for Crohn’s disease (CD) complicated with tubular intestinal fistula. Methods    Clinical data of 43 enterocutaneous fistula patients of crohn’s disease treated with semi-elemental enteral nutrition  for 3 months were retrospectively analyzed from May 2007 to December 2011,in Jinling hospital. The results of whether the fistula was closed or not were recorded after EN therapy.The closure time of fistulas were also recorded too.In order to investigate the effect of EN on crohn’s fistula,we record the inflammation index (e.g. CRP、ESR、Plt) and nutritional status indicators (e.g. body weight、BMI、Hb、ALB、PALB、TP) before and after EN therapy.The follow-up time of the fistula cured patients were at least half a year. Results    27 of these 43 fistula patients were cured after EN therapy on the average of 32.6±9.2 days. Non-specific laboratory inflammation indices (ESR、CRP and Plt) of crohn’s disease were improved significantly after EN therapy when the patients were considered as a whole (P<0.05).Though the cured group and the uncured group were both much better on inflammation indices after EN therapy,there were no significant differents between the two groups (P>0.05).The nutrition status of these patients,such as body weight、BMI、Hb、ALB、PALB、TP，increased significantly after therapy compared to that before treatment (P<0.05).The fistula cured group improved much better on serum albumin and serum prealbumin than the fistula uncured group (P<0.05). Conclusions    EN therapy on enterocutaneous fistula of CD can achieve the results of induction of clinical remission, reduction of the inflammatory reaction, improvement of the nutrition status,closure of partial patientss’ fistula and avoiding the infliction of the operation.