Evaluation of annual recurrence risk for breast cancer patients classified by immunohistochemistry molecular subtypes after radical mastectomy        FANG Qi, WANG Xu-fen. Department of Breast Surgery, the Third Affiliated Hospital of Suzhou University, Changzhou 213000, China
Corresponding author: WANG Xu-fen, E-mail:493835745@qq.com
Abstract    Objective    To analyze the prognosis feature and annual recurrence risk for breast cancer patients classified by immunohistochemistry molecular subtypes after radical mastectomy. Methods    The clinical data of 310 cases of female unilateral breast cancer performed modified radical mastectomy between January 2003 and August 2008 in the First People’s Hospital of Changzhou were analyzed retrospectively. All the cases were classified as luminal, HER2+ and triple negative subtypes according to their immunohistochemistry results of ER, PR and HER2. Survival curves were performed with Kaplan-Meier method and annual recurrence hazard was estimated by hazard function. Results    Annual recurrence hazard curve for entire population showed a double-peaked pattern, with a first major recurrence surge reaching the maximum at the second year after surgery and a second low recurrence peak near the 5th year. Compared with luminal subtype, HER+ subtype had a much higher annual recurrence peak. The annual recurrence peak of triple negative subtype breast cancer, though lower than HER2+ subtype, was still higher than luminal subtype. The peak of HER2+ subtype decreased vastly after 2-3 years. Triple negative subtype had a relative stable peak from 2-5 year. Conclusion    The annual recurrence features of breast cancer subtypes can provide different guidance for prognosis.