Clinical efficacy of high-dose induction therapy by maintenance with recombinant human erythropoietin(rhEPO) in intestinal fistula patients complicated with intra-abdominal infection with anemia        HONG Zhi-wu, REN Jian-an, LIU Song, et al. Department of General Surgery, School of Medicine, Nanjing University/Nanjing General Hospital of Nanjing Military Command, Nanjing210002, China
Corresponding  author ：REN Jian-an，E-mail:jan@medmail.com.cn
Abstract    Objective    To study clinical efficacy of recombinant human erythropoietin (rhEPO) in intestinal fistula patients complicated with intra-abdominal infection with anemia. Methods    One hundred and fourteen patients with intestinal fistula complicated with intra-abdominal infection with anemia admitted from September 2010 to December 2011 in General Hospital of Nanjing Military Command were enrolled. In accordance with the iron content of the body the patients were divided into the group with the normal iron content in the body and the group with the deficient iron content. The normal iron content group was randomly divided into nutrition support therapy group (n=30) and nutritional support combined with high-dose induction therapy by maintenance with rhEPO treatment group (n=30); iron deficiency group is divided into nutrition support therapy in combination with iron group (n=27) and nutrition support therapy in combination with iron, high-dose induction therapy by maintenance with rhEPO treatment group (n=27). All of the patients were given sufficient nutritional support, rhEPO and (or) iron sucrose injection treatment, and clinical observation was given. Results    There was no significant difference on hemoglobin between the two groups before treatment (P>0.05). After the intervention with rhEPO, the hemoglobin of the group with the normal iron content in the body was higher than in control group (P<0.05); the group with the deficient iron content in the body was higher than in control group (P<0.05). All patients demonstrated fine tolerance. Conclusion    The high-dose induction therapy by maintenance with rhEPO in intestinal fistula patients complicated with intra-abdominal infection with anemia can increase RBC and hemoglobin, relieve anemia with better treatment compliance, which is worth being studied further.