Clinical analysis of sepsis-associated liver dysfunction: an analysis of 49 patients        LIU Yi-na，MA Xiao-chun. Department of Intensive Care Unit, the First Affiliated Hospital of China Medical University，Shenyang 110001, China
Corresponding  author ：MA Xiao-chun，E-mail：xcma2972@sina.com
Abstract    Objective    To investigate the incidence，manifestation and duration of sepsis-associated liver injury，and analyze the influence of liver dysfunction on the prognosis of septic patients. Methods    The data of 150 septic patients admitted between January 2010 and December 2010 in Department of Intensive Care Unit, the First Affiliated Hospital of China Medical University were analyzed retrospectively. Among 150 patients, 49 patients（32.7%）began to involve in liver dysfunction from the first day to the twenty-third day after sepsis identified. Results    In patients with liver dysfunction, there were 17 patients （34.7%）with abnormaly high bilirubin level，22 patients（44.9%）with increasing glutamic-pyruvic transaminase, 10 patients （20.4%）with both increasing bilirubin and glutamic-pyruvic transaminase. The duration of liver dysfunction ranged from 1 to 25 days. In liver dysfunction group, the incidence of MODS was 57.1%（28/49）. The fatality rate was 34.7%（17/49）. ICU duration ranged from 1 to 107 days and mechanical ventilation duration was 9 to 1140 hours. The differences of MODS incidence, fatality rate, ICU duration and mechanical ventilation duration were statistically significant between liver dysfunction group and normal liver function group. The recovery rate of liver function was the lowest in septic patients with abnormaly high bilirubin level, while the incidence of MODS was the highest in patients with both increasing bilirubin and glutamic-pyruvic transaminase. Conclusion    Septic-associated liver dysfunction is commonly seen in ICU. Liver dysfunction contributes to a poor prognosis and high incidence of MODS in septic patients. The recovery rate of liver function is the lowest in septic patients with abnormaly high bilirubin level.