New opinion of coagulation disorders resulted from severe sepsis        ZHANG Zhi-dan. Department of Intensive Care Unit, the First Affiliated Hospital of China Medical University，Shenyang 110001, China
Abstract    Sepsis is almost invariably associated with coagulation disorders. The mechanisms underlying septic coagulopathy including tissue factor induced enhancement of procoagulation, down-regulation of physical anticoagulation pathway and inhibition of fibrinolysis. Appropriate pharmacotherapy aiming directly at different mechanisms of septic coagulopathy may be effective for severe sepsis patients.