Main risk factors of hepatocellular carcinoma recurrence related to hepatitis B virus and anti-virus therapy strategies    DOU Xiao-guang，DING Yang. Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang110004, China
Corresponding author：DOU Xiao-guang，E-mail：douxg@sj-hospital.org
Abstract    The recurrence rate of hepatocellular carcinoma (HCC) related hepatitis B virus (HBV) remains high, which is the main cause of early death even after curative hepatectomy. The postoperative risk factors for early recurrence are related to the severity of disease，cirrhotic degree，vascular invasion，intrahepatic metastasis，AFP level > 1000 ng/mL，tumor number and size，curative hepatectomy  and so on. For HCC related to HBV，preoperative high viral load and effective anti-viral therapy are the independent risk factors for overall and recurrence-free survival. The early, effective and standard anti-viral therapy has potential beneficial effects for the prevention of liver function failure, reducing of postoperative recurrence of tumor and improving the survival of patients.