Recurrence and metastasis profiles of hepatocellular carcinoma after liver transplantation and analysis of prognostic factors        LI Yan-jie，MA Yi，GUO Zhi-yong，et al. Organ Transplantation Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Corresponding author：MA Yi，E-mail：anhuimayi2002@163.com
Abstract    Objective    To explore the features of recurrence and metastasis of hepatocellular carcinoma (HCC) after liver transplantation, and analyze the risk factors influencing prognosis. Methods    The clinical and follow-up data of 121 patients who underwent liver transplantation for HCC between June 2007 and October 2010 in the First Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. The Kaplan-meier method was used to evaluate the cumulative survival rate. Log-rank test and Cox regression model were performed to analyze clinical pathologic risk factors by univariate and multivariate analysis respectively. Results    In the univariate analysis, tumor size, number and location, preoperative alpha-fetal protein (AFP) level, Edmondson patho1ogic classification, portal vein invasion and pTNM stage were found to be associated with the overall survival rate significantly. The multivariate analysis revealed that tumor size, Edmondson patho1ogic classification and portal vein invasion were the most independent, statistical and significant factors affecting survival. Conclusion    HCC is still one of the main indications of liver transplantation. Tumor size, Edmondson patho1ogic classification and portal vein invasion are the major prognostic factors after liver transplantation. Recipients can get a long-term survival if transplant candidates are selected strictly.