Analysis of prognostic related risk factors in periampullary carcinoma        FANG Yuan, XU Xue-feng, JI Yuan, et al. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Corresponding author：LOU Wen-hui, E-mail：wenhuilou@yahoo.com.cn
Abstract    Objective    To analyze the correlation between clinicopathological features and prognosis of periampullary carcinoma. Methods    The clinicopathological features and prognosis-related factors of 48 cases of periampullary carcinoma performed pancreaticoduodenectomy between February 2005 and December 2009 at Zhongshan Hospital of Fudan University were analyzed retrospectively. One-year and three-year cumulative survival rate and median survival time were calculated using life tables. Prognosis-related factors between 48 cases of periampullary carcinoma and 117 cases of pancreatic cancer followed up in the same period were compared by Kaplan-Meier method. Univariate and multivariate analysis was performed by Kaplan-Meier method and Cox Proportional Hazard Model respectively. Results Among 48 cases of periampullary carcinoma, 15 cases died and 33 cases survived. One-year and three-year cumulative survival rate was 75% and 55% respectively. The median survival time was 30 months. Among 117 cases of pancreatic carcinoma during the same follow-up period, 89 cases died and 28 cases survived. One-year and three-year cumulative survival rate was 59% and 42% respectively. The median survival time was 14 months. Univariate survival analysis revealed that tumor site, lymphatic metastasis and neural invasion were prognostic factors（P<0.05）, while differentiation grade and vessel invasion were not. Multivariate survival analysis revealed that tumor site and lymphatic metastasis were two independent prognostic factors. Conclusion    The prognosis of periampullary carcinoma is better than that of pancreatic carcinoma. Tumor site and lymphatic metastasis are two independent prognostic factors.