Analysis of postoperative survival and prognostic factors of orthotopic liver transplantation for hepatocellular carcinoma beyond UCSF criteria        YE Zhi-ming，GUO Zhi-yong，MA Yi，et al. Transplantation Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Corresponding author：MA Yi，E-mail：anhuimayi2002@163.com
Abstract    Objective    To explore postoperative survival and prognostic factors of orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) beyond UCSF criteria. Methods    The clinical and follow up data of 58 cases of HCC beyond UCSF criteria performed OLT from January 2006 to December 2010 at the First Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. Survival analysis was performed using Kaplan-Meier, Log-Rank test and Cox proportional hazards regression methods. Results    Univariate analysis showed that tumor Edmondson grade, TNM stage, portal vein tumor thrombi (PVTT), AFP>400μg/L and lymph node metastasis affected the overall survival rate and/or disease free survival rate significantly (P＜0.05). The Cox regression analysis showed that the independent factors associated with prognosis were tumor Edmondson grade III/IV and PVTT (P＜0.05). Conclusion    The effect of OLT for HCC beyond UCSF criteria is disappointing. But some cases can achieve long term survival. Tumor Edmondson grade III/IV and PVTT are important predictive factors of poor prognosis.